Neighborhood 48H guide
Santa Croce: Where to Stay & What to Do in 48 Hours
Ca’ Pesaro and the natural history museum near Piazzale Roma.
Santa Croce links Piazzale Roma and the station to the Rialto, with two Grand Canal museums: Ca’ Pesaro for modern art and the Fondaco dei Turchi for natural history.
Photo gallery
Photo: This Photo was taken by Wolfgang Moroder. · CC BY-SA 3.0 · Wikimedia Commons 
Photo: Didier Descouens · CC BY-SA 4.0 · Wikimedia Commons
Why stay here
Easy arrivals and departures, a short walk to the Rialto.
Who it's for: Travellers arriving by car or bus and those wanting value.
Pros
- Easy arrivals
- Value
- Grand Canal museums
Cons
- Busy near Piazzale Roma
- Less scenic edges
- Few sights west
48H in Santa Croce
Ca’ Pesaro and the natural history museum near Piazzale Roma.
10:00 – Ca’ Pesaro
Modern art; Gianmaria Potenza to 22 November 2026.
14:00 – Natural History Museum
In the Fondaco dei Turchi.
Named recommendations
Real places with links to their official site or a Maps place page. We do not invent hours, prices, or ratings.
See / do
See / do
Ca’ Pesaro
Fondamenta de Ca’ Pesaro
International Gallery of Modern Art in a Longhena palace; exhibitions through November 2026.
Photo: This Photo was taken by Wolfgang Moroder. · CC BY-SA 3.0 · Wikimedia Commons Official site / map →See / do
Natural History Museum
Fondaco dei Turchi
Natural history collections in the Byzantine-style Fondaco dei Turchi.
Photo: Didier Descouens · CC BY-SA 4.0 · Wikimedia Commons Official site / map →
Where to stay
Specific named properties—not vague city-wide searches. Expedia stays use tracked Creator links; others open the hotel's official site.
Roam48 may earn a commission when you book a stay through Expedia or Vrbo links on this page, at no extra cost to you. All commercial stay links use rel="sponsored nofollow".
Hotel · Expedia
Hotel Carlton on the Grand Canal
Santa Croce 578
Four-star hotel on the Grand Canal near the station.
Check rates on Expedia →
Vacation rentals
Prefer an apartment or whole home in this neighborhood? Browse Vrbo listings for Santa Croce.
In Venice, as across Italy, every short-term rental must have a national identification code (CIN) since 1 January 2025, shown on the property and in every listing. A proposed city cap of 120 rental days a year was not adopted. Before booking on Vrbo, check that the listing shows its CIN.
Browse vacation rentals in Santa Croce on Vrbo →Other ways to spend 48 hours in Venice
- San Marco — St Mark’s Basilica, the Doge’s Palace and La Fenice.
- Castello — The Arsenale, the Biennale and quieter lanes.
- Cannaregio — The Ghetto, the Ca’ d’Oro and canal-side bars.
- Dorsoduro — The Accademia, the Guggenheim and the Zattere.
- San Polo — The Rialto market and the Frari.
- Giudecca — Palladio’s Redentore and views back to San Marco.
- Lido — Beaches across the lagoon.