Neighborhood 48H guide

Sant’Ambrogio: Where to Stay & What to Do in 48 Hours

The Synagogue and Michelangelo’s house.

Great Synagogue of Florence
Photo: Yair Haklai · CC BY-SA 4.0 · Wikimedia Commons

Further east, Sant’Ambrogio is a lived-in quarter around its food market, with the green-domed Great Synagogue and Casa Buonarroti, the Michelangelo family house.

Photo gallery

Why stay here

Local and calmer, fifteen minutes’ walk from the Duomo.

Who it's for: Repeat visitors and food lovers.

Pros

  • Local
  • Food
  • Calmer

Cons

  • Fewer sights
  • Few hotels
  • Walk to the centre

48H in Sant’Ambrogio

Synagogue and Michelangelo.

  1. 10:00 – Great Synagogue

    The domed synagogue and Jewish museum.

  2. 14:00 – Casa Buonarroti

    Michelangelo’s early reliefs.

Named recommendations

Real places with links to their official site or a Maps place page. We do not invent hours, prices, or ratings.

See / do

  • Great Synagogue of Florence

    See / do

    Great Synagogue of Florence

    Via Luigi Carlo Farini 6

    Green-domed 19th-century synagogue with a Jewish museum.

    Photo: Yair Haklai · CC BY-SA 4.0 · Wikimedia Commons
    Official site / map →

  • See / do

    Casa Buonarroti

    Via Ghibellina 70

    The Michelangelo family house, with two of his earliest marble reliefs.

    Official site / map →

Where to stay

Specific named properties—not vague city-wide searches. Expedia stays use tracked Creator links; others open the hotel's official site.

Roam48 may earn a commission when you book a stay through Expedia or Vrbo links on this page, at no extra cost to you. All commercial stay links use rel="sponsored nofollow".

Vacation rentals

Prefer an apartment or whole home in this neighborhood? Browse Vrbo listings for Sant’Ambrogio.

Since 1 January 2025, every Italian short-term and tourist rental must have a national identification code (CIN), shown in every online listing and outside the building. Hosts face fines of €800–8,000 for having no CIN and €500–5,000 for not displaying it. Before booking on Vrbo, check that the listing shows a CIN.

Browse vacation rentals in Sant’Ambrogio on Vrbo →

Other ways to spend 48 hours in Florence