Neighborhood 48H guide
Termini & Esquilino: Where to Stay & What to Do in 48 Hours
The main station and the Roman National Museum.
The streets around Roma Termini are the city’s transport hub, with Palazzo Massimo’s ancient art and Santa Maria Maggiore close by.
Photo gallery
Photo: Thomas Dahlstrøm Nielsen · CC BY-SA 4.0 · Wikimedia Commons 
Photo: Livioandronico2013 · CC BY-SA 4.0 · Wikimedia Commons
Why stay here
Trains, metro lines and airport links at the door.
Who it's for: Budget travellers and day-trippers.
Pros
- Transport hub
- Better value
- Palazzo Massimo
Cons
- Gritty in places
- Less charm
- Busy traffic
48H by Termini
Museum, then a train.
09:30 – Palazzo Massimo alle Terme
Tuesday–Sunday 9:30–19:00; closed Mondays.
13:00 – Train out
Day trips from Termini.
Named recommendations
Real places with links to their official site or a Maps place page. We do not invent hours, prices, or ratings.
See / do
See / do
Palazzo Massimo alle Terme
Largo di Villa Peretti
Roman frescoes, mosaics and the Discobolus.
Photo: Livioandronico2013 · CC BY-SA 4.0 · Wikimedia Commons Official site / map →
Where to stay
Specific named properties—not vague city-wide searches. Expedia stays use tracked Creator links; others open the hotel's official site.
Roam48 may earn a commission when you book a stay through Expedia or Vrbo links on this page, at no extra cost to you. All commercial stay links use rel="sponsored nofollow".
Hotel · Expedia
Hotel Termini
Esquilino
2-star hotel with a 24-hour front desk, by the station.
Check rates on Expedia →
Vacation rentals
Prefer an apartment or whole home in this neighborhood? Browse Vrbo listings for Termini & Esquilino.
Italian short-term rental listings must show a national identification code (CIN). Check that the listing shows one, plus its house rules.
Browse vacation rentals in Termini & Esquilino on Vrbo →Other ways to spend 48 hours in Rome
- Pantheon & Piazza Navona — The Pantheon, Piazza Navona and the old-centre lanes.
- Trevi & Quirinale — The Trevi Fountain and the Quirinal hill.
- Spanish Steps & Via del Corso — The Spanish Steps, Via Condotti and the Ara Pacis.
- Piazza del Popolo & Villa Borghese — The Borghese Gallery and the city’s great park.
- Campo de’ Fiori & Via Giulia — The morning market and Renaissance streets.
- Monti & the Colosseum — The Colosseum, the Forum and Rome’s oldest rione.
- Trastevere — Cobbled lanes, piazzas and trattorias across the river.
- Vatican & Prati — St. Peter’s, the Vatican Museums and Castel Sant’Angelo.
- Aventine & Testaccio — The orange garden, the keyhole and Roman food.